Benzodiazepines List: Safe Use vs. Abuse Risks

Medical Providers:
Dr. Randy Gelow, MD, FASAM
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: September 4, 2025

Benzodiazepines, or benzos, are medicines doctors give to help calm the brain. They are often used to treat anxiety, panic attacks, seizures, muscle spasms, and trouble sleeping. Benzodiazepines work well when taken as prescribed. But they can also lead to dependence, misuse, or addiction.

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A Complete Benzodiazepines List

Benzodiazepines come in many types, each with specific uses, strengths, and effects. Below is a complete list of commonly prescribed benzodiazepine drugs, including their brand names and what they’re used for.

Alphrazolam

  • Brand Name: Xanax
  • Common Uses:  Anxiety disorders, panic disorders 

Clonazepam

  • Brand Name: Klonopin
  • Common Use:  Seizure disorders, panic disorders

Diazepam

  • Brand Name:  Diazepam Valium
  • Common Use: Anxiety, muscle spasms, alcohol withdrawal

Lorazepam

  • Brand Name: Ativan
  • Common Use: Anxiety, seizures, preoperative sedation

Temazepam

  • Brand Name: Restoril
  • Common Use: Insomnia

Chlordiazepoxide

  • Brand Name: Librium
  • Common Use: Alcohol Withdrawal, anxiety

Oxazepam

  • Brand Name:  Serax
  • Common Use: Anxiety, alcohol withdrawal

Triazolam

  • Brand Name: Halcion
  • Common Use: Short term insomnia

Midazolam

  • Brand Name: Versed
  • Common Use: Sedation for surgery, seizures (especially in children)

Flurazepam

  • Brand Name: Dalmane
  • Common Use: Insomnia

Each benzodiazepine varies in potency, duration of action, and purpose. Some are fast-acting for acute anxiety episodes, while others are long acting benzo for chronic issues like seizures.

List of Benzodiazepine Drugs from Strongest to Weakest

The benzodiazepines list in order of strength is based on potency per milligram and their effects on the central nervous system. 

  • Clonazepam – very high 
  • Alprazolam- very high 
  • Lorazepam – high 
  • Triazolam – high
  • Midazolam- high
  • Diazepam – moderate 
  • Temazepam – moderate
  • Chlordiazepoxide – moderate 
  • Flurazepam – low
  • Oxarepam – low

Clonazepam and Alprazolam are considered some of the strongest benzodiazepines, even in small doses. Diazepam has a long half-life, but it’s less potent per mg compared to others.

Potency does not always equal danger. But high potency drugs may lead to faster physical dependence and withdrawal risk.

Long-Acting Benzos

The long acting benzodiazepines list includes drugs which stay in the body longer and have extended therapeutic effects.

  • Diazepam: 20 –100 hours
  • Clonazepam: 18 –50 hours
  • Chlordiazepoxide: 24 –48 hours
  • Flurazepam: 40-250 hours
  • Clorazepate – 36-200 hours
  • Nordazepam – 36-200 hours

These benzos take longer to take effect but last longer in the system.

Short-Acting Benzos

The short acting benzodiazepines list includes drugs that have a quick onset and a relatively short half-life, fast action, and short duration in the body.

  • Triazolam – 1.5-5.5 hours
  • Midazolam – 1.5-3 hours
  • Oxazepam- 5-15 hours
  • Temazepam – 8-20 hours
  • Alprazolam – 6-12 hours
  • Lorazepam – 10-20 hours

Short-acting benzos often lead to more intense withdrawal symptoms if stopped abruptly.

Intermediate Acting Benzos

Here’s a list of intermediate acting benzodiazepines, which have a moderate half-life.

  • Lorazepam- 10-20 hours
  • Temazepam – 8-20 hours
  • Aplprazolam – 6-12 hours
  • Oxazepam- 5-15 hours

These benzos stay in the body longer than short-acting ones, but not as long as long-acting ones. However, they still require careful tapering to avoid withdrawal symptoms.

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How Benzodiazepines Work

Benzodiazepines enhance the effect of a neurotransmitter called GABA (gamma-aminobutyric acid) in the brain. GABA inhibits brain activity, promoting calmness, reducing anxiety, and aiding sleep. Benzos increase GABA’s effects, which is why they’re so effective at calming the central nervous system.

However, this same calming effect is what makes them prone to substance abuse. The body can grow tolerant to their effects. Thus, users tend to take higher doses, sometimes without medical supervision.

Benzos can have both positive and negative effects on mental health, depending on how they’re used. They are highly effective for short-term relief of anxiety and related conditions. However, long-term use or misuse can lead to serious mental health consequences.

Signs of Benzo Misuse or Abuse

A 2018 study by the National LIbrary of Medicine showed that 30.6 million of adults in the US use benzodiazepines responsibly, or as prescribed, annualy the past year.  However, another 5.3 million fall into patterns of misuse and experience the effects of benzodiazepines.

  • Taking benzos to “feel good” or escape emotions
  • Mixing with other substances (especially alcohol or opiois)
  • Doctor shopping to get multiple prescriptions
  • Crushing or snorting pills for a more potent effect

Recognizing these warning signs early can prevent serious side effects, health risks, and long-term damage. If you notice these symptoms in yourself or someone else, it may be time to seek help for benzodiazepine addiction.

The Risk of Dependence and Addiction

Long-term use of Benzos can be habit-forming. Over time, the brain may stop producing natural calming chemicals (like GABA) and become reliant on the drug.

Symptoms of Benzo Dependence

  • Needing higher doses to feel the same effect (tolerance)
  • Feeling anxious, shaky, or irritable without the drug
  • Being unable to stop even when you want to (loss of control)

Benzodiazepine Withdrawal Symptoms:

  • Anxiety and panic attacks
  • Insomnia
  • Muscle pain and tremors
  • Seizures (in severe cases)
  • Hallucinations or confusion

These symptoms can begin within hours to days after stopping the drug. They may also vary depending on the duration of usage and dosage.

Don’t let fear of withdrawal hold you back. Healing starts with professional support.

When to Seek Help

If you or someone you love is showing signs of benzodiazepine misuse or addiction, it’s important to seek addiction treatment. Stopping cold turkey can be dangerous. Medical detox and behavioral therapy offer a safer, more effective path toward recovery.

Red flags that signal it is time to get help:

  • Obsessing over medication or running out early
  • Isolation from family and friends
  • Mood swings, paranoia, or memory problems
  • Failed attempts to quit or cut back

Know the List, Know the Risks

The benzodiazepine medication list is not risk-free. When prescribed appropriately and used under close medical supervision, benzodiazepines are safe and effective for short-term treatment.

Understanding the complete list of commonly prescribed benzos and how they’re meant to be used can help you or a loved one stay safe. If you’re struggling with use, you’re not alone. Support and effective treatment are available.

Need Help with Benzodiazepine Dependence?

Benzo dependence is serious. Drug abuse is a severe condition. But with medical detox, therapy, and ongoing support, safe recovery is achievable. Contact our admissions team, and we will discuss the next steps in your recovery journey.

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