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Zoloft Side Effects: Risks, Frequency & What to Expect

Medical Providers:
Dr. Randy Gelow, MD, FASAM
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: August 18, 2025

Starting Zoloft (sertraline) can feel like a balancing act—hoping for relief from depression or anxiety, while worrying about potential side effects. You’re not alone. According to the FDA’s prescribing information, about 26% of patients reported nausea, 20% experienced diarrhea, and around 11% had drowsiness during clinical trials—rates significantly higher than those taking a placebo.

If you’re among those dealing with unexpected changes—sleepless nights, digestive issues, or shifts in your mood—understanding what’s happening and knowing how to cope can make all the difference. This article will guide you through the most frequent Zoloft side effects, how to spot serious warning signs, and compassionate, practical ways to manage them, so you can stay on track with your healing journey.

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(Sertraline) Zoloft Side Effects

What Are the Side Effects of Zoloft?

Zoloft, which is the brand name for the generic drug sertraline, is a widely prescribed antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) family. Like any medication, it can cause side effects, though not everyone experiences them—and those who do may notice them to varying degrees.

Before starting Zoloft, it’s always a good idea to talk with your healthcare provider about what to expect. Some of the most commonly reported side effects include:

  • Nausea
  • Diarrhea or upset stomach
  • Trouble sleeping or insomnia
  • Drowsiness or fatigue
  • Headaches
  • Dry mouth
  • Increased sweating
  • Changes in appetite
  • Weight loss or gain

Being aware of these potential reactions can help you better manage your treatment and know when to reach out for guidance if any symptoms become disruptive.

How Long Does Side Effects of Zoloft Last?

The duration of side effects from Zoloft (sertraline) can vary widely among individuals. Some effects that might happen because of the medicine could go away quickly, like in a few days or weeks. But there are also effects that could stay around for a longer time. Remember, not everyone will feel all of these effects, and how bad they are and how long they last can be different for each person.

Symptoms of Zoloft Use

Zoloft (sertraline) is mainly prescribed as an antidepressant and isn’t considered addictive in the traditional sense. That said, like any medication, it can become problematic if it’s not used as directed.

Problems can arise when someone takes more than prescribed, uses it differently than intended, or relies on it too heavily. Warning signs include needing higher doses to feel the same effect, feeling uneasy or unwell when stopping, and constantly thinking about getting or taking the medication.

If you or a loved one notice these behaviors with Zoloft, it’s important to reach out to a healthcare professional. They can provide guidance, ensure safe use, and help prevent complications. Learn more about treatment for antidepressant misuse and detox through our comprehensive programs.

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Short and Long Term Side Effects of Zoloft

What Are the Short-term Side Effects of Zoloft?

Short-term side effects of Zoloft (sertraline) usually show up when someone first begins the medication or after a dosage change. For most people, these effects are temporary and often fade as the body gets used to the treatment. Not everyone will experience them, and the intensity can differ from person to person. Some of the more common short-term side effects include:

It’s common for people to feel nauseous when they first start taking Zoloft. Usually, this discomfort is short-lived and tends to improve within a few days or weeks as your body adapts.

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Many individuals notice headaches during the early stages of Zoloft treatment. Fortunately, these often ease on their own as your body gets used to the medication.

photo of woman experiencing headache

Some people may feel dizzy or lightheaded, especially when standing up quickly. This side effect typically fades as your body adjusts to the medication over time.

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Feeling unusually tired or worn out is a common early side effect of Zoloft. Most people find that this gradually eases as their body becomes accustomed to the medication.

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Some individuals may experience digestive issues, such as diarrhea, an upset stomach, or changes in bowel habits when starting Zoloft. These symptoms usually improve as your system adjusts to the medication.

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Gastrointestinal symptoms like diarrhea, upset stomach, or changes in bowel habits can occur initially. These symptoms often improve as your body adjusts to the medication.

a man who is feeling dehydrated and wiping off his sweat due to intense exercising

Some people notice increased sweating when they start taking Zoloft. This side effect is usually mild and often improves as your body gets used to the medication.

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Feeling restless, on edge, or unusually agitated can occur, especially during the first few weeks of treatment. For many, these sensations settle down as the body adjusts.

photo example of couple in bed experiencing sexual issue

Zoloft can sometimes affect sexual function, including reduced desire, difficulty achieving orgasm, or other changes. Open communication with your healthcare provider can help manage these effects while staying on the medication safely.

What Are the Long-term Side Effects of Zoloft?

Most people find that Zoloft side effects are mild and go away after their body gets used to the medication. Still, when taken over a longer period, some individuals may notice ongoing effects. Everyone responds differently, so not all people will have the same experience. Some of the possible long-term side effects of Zoloft can include:

  • 7 Long-term Side Effects of Zoloft

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  • Sexual Dysfunction

    Some people notice changes in their sex life while taking Zoloft. This can mean a lower interest in sex, trouble with erections for men, or difficulty reaching orgasm. For some, these problems may continue even after stopping the medication.

  • Weight Gain

    Zoloft may cause weight gain in certain individuals, though it varies from person to person. Over time, this can make it harder to manage weight, especially if other lifestyle factors are involved.

  • Serotonin Trouble

    While rare, too much serotonin in the body can be dangerous. This is known as serotonin syndrome. It’s more likely to happen if Zoloft is taken with other medicines or recreational drugs that also raise serotonin levels.

  • Bones and Pills

    There’s some evidence that long-term use of medicines like Zoloft may slightly affect bone strength, which could raise the chance of fractures. The risk is small, but it’s something to be aware of.

  • Withdrawal and Discontinuation Syndrome

    If someone stops Zoloft suddenly, they might feel flu-like symptoms, dizziness, irritability, mood changes, or odd sensations. Slowly tapering off with a doctor’s guidance can help ease this process.

  • Bleeding Risk

    SSRIs, including Zoloft, may slightly increase the risk of bleeding, especially for those also taking blood thinners or medicines that affect clotting.

  • Cardiovascular Effects

    In very rare cases, long-term SSRI use has been linked to changes in heart rate or rhythm. This risk is small and usually more of a concern for people who already have heart conditions.

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Zoloft Side Effects for Men and Women

Zoloft Side Effects in Men

Men taking Zoloft (sertraline) may notice different side effects, though everyone’s experience can be a little different. Some men report challenges with sexual health, including difficulty getting or keeping an erection, a lower interest in sex, or trouble reaching orgasm. Weight gain can also occur over time for some individuals.

There’s also a rare but serious risk of serotonin syndrome, especially if Zoloft is taken alongside other medications or substances that raise serotonin levels. This condition can cause symptoms like confusion, rapid heartbeat, or high blood pressure, and should be treated quickly if it happens.

If these side effects start to affect your well-being, it’s important to talk with a doctor or pharmacist about your options. And if Zoloft use becomes difficult to manage, our team at The Hope House can provide support through personalized mental health and recovery programs.

Zoloft Side Effects in Women

Women taking Zoloft (sertraline) can sometimes notice side effects, though everyone’s body reacts differently. Some may find changes in their sexual health, like a lower interest in sex, trouble reaching orgasm, or shifts in arousal. Weight gain can also be an issue for some over time.

There’s also a small chance of developing serotonin syndrome, a condition that happens when there’s too much serotonin in the body. This risk is higher if Zoloft is taken with other medications or substances that also affect serotonin levels.

If these side effects become bothersome or don’t go away, it’s best to reach out to a doctor or healthcare provider to talk through the options.

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Treating Side Effects of Zoloft

If you or someone close to you is struggling with Zoloft use or dealing with difficult side effects, reaching out for help can make all the difference. At The Hope House in Scottsdale, Arizona, we specialize in providing compassionate, individualized care in a supportive, upscale environment.

Our team creates personalized recovery plans — including dual diagnosis treatment when needed — to address both mental health and substance use concerns. You don’t have to face this alone. Connect with our team today and take the first step toward lasting healing and a healthier future.

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