How Long Does Ativan Stay In Your System? Ativan Half Life

Medical Providers:
Dr. Randy Gelow, MD, FASAM
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: August 19, 2025

Ativan, or lorazepam, is a type of benzodiazepine that doctors often prescribe for anxiety, trouble sleeping, or even seizures. While it can be effective, it also carries a risk of dependence and misuse, just like other medications in this class.

In fact, research from the National Institute on Drug Abuse (NIDA) shows that benzodiazepine misuse has been on the rise. Worryingly, nearly 30% of opioid overdose deaths also involve benzodiazepines.

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How long does Ativan stay in your system? The answer depends on a few different factors, including your metabolism, age, and overall health. On average, Ativan has a half-life of about 12 hours, meaning it takes that long for your body to clear half of the drug. But it doesn’t leave right away—since it takes several half-lives for complete elimination, Ativan can remain in your system for about 2–3 days before it’s fully cleared.

Factors That Affect Ativan’s Duration in the System

When asking how long Ativan stays in your system, it’s important to remember that the answer isn’t the same for everyone. Factors like your age, body weight, metabolism, and liver health all affect how quickly your body processes and clears the drug. Someone with a faster metabolism or a healthy liver may eliminate Ativan more quickly, while others may take longer.

Age

For older adults, a naturally slower metabolism can make a big difference in how long Ativan stays in your system. It often lingers longer compared to younger people.

Weight

If someone is overweight or obese, their body may process medications more slowly. As a result, Ativan may stay in your system longer than it would for someone at a healthy weight.

Gender

Women usually metabolize drugs at a slower rate than men. This means Ativan can stay in a woman’s system longer, leading to extended detection times.

Metabolism

Everyone’s metabolism is unique. People with a faster metabolism may clear Ativan more quickly, while certain liver conditions or medications that affect liver enzymes can slow the process and make Ativan stay in your system longer.

Other Medications

Taking other drugs or mixing Ativan with substances like alcohol or opioids can interfere with how it’s broken down. This not only affects how long Ativan stays in your system but also raises the risk of dangerous side effects.

Drug or Substance Abuse

When Ativan is misused or taken in higher doses, the body takes longer to eliminate it. In these cases, Ativan can remain in your system for an extended period of time.

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To better understand how long Ativan stays in your system, it helps to look at its half-life. On average, Ativan’s half-life is about 12 hours. This means that after 12 hours, your body has cleared roughly half of the dose. Another 12 hours later, half of what’s left is gone, and the process continues until the drug is fully eliminated.

Keep in mind, though, that this timeline can vary. Factors like age, metabolism, liver health, and overall wellness can all influence how quickly—or slowly—Ativan leaves your system.

Does Ativan Show In Drug Test?

When it comes to drug testing, Ativan can show up in urine, blood, saliva, and even hair tests. The amount of time it remains detectable depends on the type of test being used.

These timeframes aren’t exact, though. Factors like your metabolism, how often you take Ativan, and your overall health can all affect how long Ativan stays in your system.

Here are the general detection windows:

urine test icon to detect use of drugs

Urine Test

Ativan can typically be detected in urine for up to 6 days after the last dose.

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Blood Test

Ativan can usually be detected in the blood for up to 2-3 days after the last use.

saliva test icon to detect drug substance

Saliva Test

Ativan can be detected in saliva for up to 8 hours after the last dose.

hair test icon for accurate evidence of drug use

Hair Test

Ativan can be detected in hair samples for a much longer period, up to 30 days or more after the last use.

How long does it take for Ativan to wear off?

For most people, the calming effects of a single dose of Ativan usually fade within a few hours. That said, how long Ativan stays in your system doesn’t always match how long you feel its effects. Even after the drug has mostly cleared, some residual side effects—like drowsiness, slower reflexes, or problems with coordination—can still linger.

If you’re trying to figure out exactly when Ativan will be completely out of your system, the safest approach is to talk with a healthcare professional. They can take into account your metabolism, overall health, and medical history to give you guidance that’s specific to your situation.

False Positives

Sometimes, drug tests for Ativan or other benzodiazepines can show a false positive—even if you haven’t actually taken the medication. This usually happens when other prescriptions interfere with the results. For example, certain medications like Efavirenz (used for HIV), Sertraline (commonly prescribed for depression and anxiety), or Oxaprozin (a pain reliever) may trigger a positive test.

If you ever receive a positive result and you know you haven’t used Ativan, it’s important to follow up with your doctor. They can review your medications and may order a more accurate confirmatory test to rule out a false positive and give you peace of mind.

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If you or someone close to you is struggling with Ativan addiction, getting professional support can make all the difference. At The Hope House, a premier residential treatment center in Scottsdale, Arizona, we provide compassionate and effective care for those ready to take back control of their lives.

Our holistic approach goes beyond treating symptoms—we work to uncover the root causes of addiction while creating personalized treatment plans for every client. With a team of experienced medical professionals, we recognize that no two recovery journeys are the same, and we tailor our therapies to support each person’s unique path to lasting healing.

At The Hope House, we’ve created a peaceful, private setting where healing truly begins. Our comfortable accommodations and calming environment make it easier for clients to focus fully on recovery without outside distractions.

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