How Long Does GHB Stay In Your System: What You Need to Know

Medical Providers:
Dr. Michael Vines, MD
Alex Spritzer, FNP, CARN-AP, PMHNP
Clinical Providers:
Natalie Foster, LPC-S, MS
Last Updated: February 2, 2026

Gamma hydroxybutyrate (GHB) is a powerful central nervous system depressant commonly known as a club drug or the “date rape drug” due to its association with sexual assault cases. It is often used recreationally for its sedative and euphoric effects. According to the National Survey on Drug Use and Health, an estimated 1.2 million people in the United States have reported using GHB, with rates reaching 12% among regular ecstasy and stimulant users. GHB is a highly addictive substance that can have severe effects on both physical and mental health.

GHB moves through the body quickly, with a half-life of just 30 minutes to one hour in most adults. This short window is one reason it’s so dangerous—people often underestimate how unpredictable it can be, especially when doses are repeated or mixed with alcohol. The effects typically last three to four hours, but higher doses can extend them to six hours or longer. Understanding how long GHB stays in your system is crucial for effective addiction treatment, clarifying drug testing results, and making safer decisions moving forward.

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GHB moves through the body quickly. After use, it is absorbed rapidly and broken down mainly by the liver. Unlike many drugs, it does not linger in fat tissue for long periods. Most of it is converted into inactive byproducts and eliminated through urine. For comprehensive information on how GHB and other substances are processed, see our guide on how long drugs stay in your system.

For most people, GHB begins leaving the system within a short time. That does not mean it is safe. The fast clearance often leads people to redose, which increases overdose risk and makes side effects harder to predict.

The half-life of GHB is short. In most adults, it ranges from 30 minutes to about one hour. This means half of the substance is removed from the bloodstream during that time. According to the National Institute on Drug Abuse (NIDA), GHB’s rapid metabolism is one reason why it’s considered particularly dangerous in recreational settings.

Even though the half-life is brief, the body does not clear GHB instantly. Complete processing usually takes two to five hours, depending on the person. Factors like body weight, liver health, metabolism, and whether other substances were used at the same time can change this timeline. Learn more about GHB-specific drug detection information.

How long do the effects of GHB last?

The effects often begin within 10 to 30 minutes. Many people feel relaxed, sleepy, or euphoric. These effects typically last three to four hours, but higher doses or repeated use can extend them to six hours or longer. In overdose situations, sedation and breathing suppression may persist well beyond that window.

Understanding GHB: Effects and Risks

GHB, often found as a white powder or liquid ecstasy, acts as a potent depressant on the central nervous system.

Its effects can range from relaxation and euphoria to loss of consciousness and memory loss. While some individuals may initially misuse GHB for recreational purposes, the risk of dependence and severe side effects is high.

Does GHB show on a drug test?

Yes, but detection can be difficult. GHB is not always included in standard drug panels and has a narrow detection window.

The detection of GHB in drug tests can provide crucial information for diagnosing addiction and monitoring treatment progress. Different types of drug tests can be used to detect the presence of GHB in the body. However, detection through a drug test for GHB is challenging because of short detection windows.

GHB Detection Windows

urine test icon to detect use of drugs

Urine Tests

Most commonly detect GHB within 12 hours, though some advanced tests may detect it for up to 72 hours

sample blood icon for blood testing for drug use

Blood Tests

Typically detect GHB for 6 to 8 hours after use

saliva test icon to detect drug substance

Saliva Tests

Similar to blood testing, usually up to 8 hours

hair test icon for accurate evidence of drug use

Hair Tests

Can show prior use for up to 90 days, but these tests are rare and usually limited to forensic settings

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Dosage and Frequency of Use

Larger doses and repeated use increase how long GHB and its byproducts remain detectable. Frequent redosing also increases medical risk.

Individual Factors

Metabolism, age, body composition, and liver function all influence how quickly GHB is processed. Some people naturally eliminate it faster than others.

Interactions with Other Substances

The use of other substances, such as alcohol or drugs, can interact with GHB and alter its duration in the system. Combining GHB with other depressants, like alcohol, can have synergistic effects, potentially leading to dangerous outcomes. It is crucial to understand the risks and side effects associated with combining substances.

Mode of Administration

Most recreational use involves swallowing GHB. While absorption is fast, the amount taken and timing between doses still matter.

GHB use can become dangerous quickly, even for people who believe they are in control. Its short duration, rapid onset, and strong sedative effects create a high risk for overdose, dependence, and accidental harm. GHB is classified as a Schedule I/II controlled substance by the DEA and is only approved for medical use in treating narcolepsy under the brand name Xyrem.

Recreational use is illegal and carries serious health risks. Learn more about the most addictive substances and how they affect the brain.

If you or someone you care about is struggling with GHB use, professional support can make a real difference. At The Hope House in Scottsdale, Arizona, we take time to understand each person’s situation and provide care that addresses both physical safety and long-term recovery.

Our team uses evidence-based treatment, medical oversight, and individualized planning to help people regain stability and move forward with confidence.

You are not alone. Get healing and support from The Hope House.

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